image/svg+xmlTGGCCGCGA
seq−5
CCTCAAATCACTCTATGGCCGCGA
seq−2
CCACAAATCACGTTATGGCCGCGA
ArgProGlnThrIleThrLeuTrpGlnPro
seq−1
CCACAAACCACGTTATGGCAG
seq−3
CGACCTCAAACCACTCTATGGCAGCGA
seq−4
CCTCAAATCACTCTA
ACC
ATC
ATC
ATC
ACC
ACC
ATC
ATC
ATC
ACC
ATC
ATC
ACC
ACC
ACC
ATC
ATC
mutation history
sample
Use sampledmutation histories to estimate rates...
but suchestimatescan be unstable.